The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway
dc.contributor.buuauthor | Erkan, Leman Gizem | |
dc.contributor.buuauthor | Güvenç, Gökçen | |
dc.contributor.buuauthor | Altınbaş, Burçin | |
dc.contributor.buuauthor | Niaz, Nasır | |
dc.contributor.buuauthor | Yalçın, Murat | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-5600-8162 | tr_TR |
dc.contributor.researcherid | AAR-6815-2021 | tr_TR |
dc.contributor.researcherid | AAG-6956-2021 | tr_TR |
dc.contributor.scopusid | 56529371200 | tr_TR |
dc.contributor.scopusid | 56529426800 | tr_TR |
dc.contributor.scopusid | 55356919300 | tr_TR |
dc.contributor.scopusid | 57060367600 | tr_TR |
dc.contributor.scopusid | 57192959734 | tr_TR |
dc.date.accessioned | 2022-12-12T11:23:04Z | |
dc.date.available | 2022-12-12T11:23:04Z | |
dc.date.issued | 2015-12-31 | |
dc.description.abstract | Arachidonic acid (AA) is a polyunsaturated fatty acid that is present in the phospholipids of the cell membranes of the body and is abundant in the brain. Exogenously administered AA has been shown to affect brain metabolism and to exhibit cardiovascular and neuroendocrine actions. However, little is known regarding its respiratory actions and/or central mechanism of its respiratory effects. Therefore, the present study was designed to investigate the possible effects of centrally injected AA on respiratory system and the mediation of the central cyclooxygenase (COX) to thromboxane A2 (TXA2) signaling pathway on AA-induced respiratory effects in anaesthetized rats. Intracerebroventricular (i.c.v.) administration of AA induced dose- and time-dependent increase in tidal volume, respiratory rates and respiratory minute ventilation and also caused an increase in partial oxygen pressure (pO2) and decrease in partial carbon dioxide pressure (pCO2) in male anaesthetized Sprague Dawley rats. I.c.v. pretreatment with ibuprofen, a non-selective COX inhibitor, completely blocked the hyperventilation and blood gases changes induced by AA. In addition, central pretreatment with different doses of furegrelate, a TXA2 synthesis inhibitor, also partially prevented AA-evoked hyperventilation and blood gases effects. These data explicitly show that centrally administered AA induces hyperventilation with increasing pO2 and decreasing pCO2 levels which are mediated by the activation of central COX to TXA(2) signaling pathway. | en_US |
dc.identifier.citation | Erkan, L. G. vd. (2016). "The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway". Respiratory Physiology and Neurobiology, 225, 1-7. | en_US |
dc.identifier.endpage | 7 | tr_TR |
dc.identifier.issn | 1569-9048 | |
dc.identifier.issn | 1878-1519 | |
dc.identifier.pubmed | 26767978 | tr_TR |
dc.identifier.scopus | 2-s2.0-84954446947 | tr_TR |
dc.identifier.startpage | 1 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.resp.2015.12.010 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1569904815301002 | |
dc.identifier.uri | http://hdl.handle.net/11452/29819 | |
dc.identifier.volume | 225 | tr_TR |
dc.identifier.wos | 000373537300001 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Respiratory Physiology and Neurobiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.relation.tubitak | 114O093 | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Physiology | en_US |
dc.subject | Respiratory system | en_US |
dc.subject | Arachidonic acid | en_US |
dc.subject | Cyclooxygenase | en_US |
dc.subject | Thromboxane A2 | en_US |
dc.subject | Tidal volume | en_US |
dc.subject | Respiratory rate | en_US |
dc.subject | Respiratory minute ventilation | en_US |
dc.subject | Partial oxygen pressure | en_US |
dc.subject | Partial carbon dioxide pressure | en_US |
dc.subject | Intracerebroventricular | en_US |
dc.subject | Hemorrhaged hypotensive rats | en_US |
dc.subject | Phospholipase A(2) activator | en_US |
dc.subject | Central histaminergic system | en_US |
dc.subject | Peripheral mechanism | en_US |
dc.subject | Breathing movements | en_US |
dc.subject | Fetal lambs | en_US |
dc.subject | Melittin | en_US |
dc.subject | Cascade | en_US |
dc.subject | Pressor | en_US |
dc.subject.emtree | Arachidonic acid | en_US |
dc.subject.emtree | Furegrelate | en_US |
dc.subject.emtree | Ibuprofen | en_US |
dc.subject.emtree | Prostaglandin synthase | en_US |
dc.subject.emtree | Thromboxane A2 | en_US |
dc.subject.emtree | Arachidonic acid | en_US |
dc.subject.emtree | Benzofuran derivative | en_US |
dc.subject.emtree | Carbon dioxide | en_US |
dc.subject.emtree | Enzyme inhibitor | en_US |
dc.subject.emtree | Furegrelate | en_US |
dc.subject.emtree | Ibuprofen | en_US |
dc.subject.emtree | Oxygen | en_US |
dc.subject.emtree | Prostaglandin synthase | en_US |
dc.subject.emtree | Respiratory tract agent | en_US |
dc.subject.emtree | Thromboxane A2 | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Anesthesia | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Blood gas | en_US |
dc.subject.emtree | Breathing rate | en_US |
dc.subject.emtree | Carbon dioxide tension | en_US |
dc.subject.emtree | Chronotherapy | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Gas analysis equipment | en_US |
dc.subject.emtree | Hyperventilation | en_US |
dc.subject.emtree | Lung minute volume | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Oxygen tension | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Respiratory function | en_US |
dc.subject.emtree | Respiratory system | en_US |
dc.subject.emtree | Signal transduction | en_US |
dc.subject.emtree | Tidal volume | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Breathing | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Enzymology | en_US |
dc.subject.emtree | Intracerebroventricular drug administration | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Respiratory system | en_US |
dc.subject.emtree | Sprague dawley rat | en_US |
dc.subject.emtree | Time factor | en_US |
dc.subject.mesh | Anesthesia | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arachidonic acid | en_US |
dc.subject.mesh | Benzofurans | en_US |
dc.subject.mesh | Carbon dioxide | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Enzyme inhibitors | en_US |
dc.subject.mesh | Ibuprofen | en_US |
dc.subject.mesh | Injections, intraventricular | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Oxygen | en_US |
dc.subject.mesh | Prostaglandin-endoperoxide synthases | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Respiration | en_US |
dc.subject.mesh | Respiratory system | en_US |
dc.subject.mesh | Respiratory system agents | en_US |
dc.subject.mesh | Thromboxane A2 | en_US |
dc.subject.mesh | Tidal volume | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.scopus | Histamine H4 Receptors; Thioperamide; Intracerebroventricular Drug Administration | en_US |
dc.subject.wos | Physiology | en_US |
dc.subject.wos | Respiratory system | en_US |
dc.title | The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 (Physiology) | en_US |
dc.wos.quartile | Q4 (Respiratory system) | en_US |
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