Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat

dc.contributor.buuauthorGüleç Süyen, Güldal
dc.contributor.buuauthorİşbil Büyükcoşkun, Naciye
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0863-1547tr_TR
dc.contributor.orcid0000-0003-0841-8201tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.researcheridAAG-7070-2021tr_TR
dc.contributor.researcheridC-5730-2015tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid6602597846tr_TR
dc.date.accessioned2022-01-14T07:32:22Z
dc.date.available2022-01-14T07:32:22Z
dc.date.issued2010-08
dc.description.abstractGlucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat. Rats were pretreated with GLP-1 (1-1000 ng/5 mu l: i.c.v.) or saline (5 mu l; i.c.v.) 30 min before seizure induction by pilocarpine (2.4 mg/5 mu l; i.c.v.) and with GLP-1 (1, 10, 100 ng/5 mu l; i.c.v.) or saline (5 mu l; i.c.v.) 30 min before the open field test or the elevated plus maze test. GLP-1 did not produce any protective effect against pilocarpine-induced seizures and did not also produce statistically significant differences in the number of squares visited (measure of locomotor activity) or number of rearings (measure of exploratory behaviour), compared to the saline-treated rats in the open field test. On the other hand, GLP-1 (1 ng and 10 ng; icy.) induced an anxiogenic effect, indicated by a decrease in the time spent in open arms, an increase in the time spent in closed arms, and a decrease in the anxiety scores in the elevated plus maze test. Pretreatment with an arginine vasopressin (AVP) V(1) receptor antagonist (125 ng/5 mu l; i.c.v.) and L-NAME (100 mu g/5 mu l and 200 mu g/5 mu l) significantly abolished the anxiogenic effect of GLP-1 (1 ng/5 mu l; i.c.v.). These results suggest that, centrally-injected GLP-1 produces anxiogenic effects via NO pathway and AVP V(1) receptors, but does not have any effects on pilocarpine-induced seizures or locomotor and exploratory activity in the open field test.en_US
dc.identifier.citationGüleç, G. vd. (2010). "Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat". Neuropeptides, 44(4), 285-291.en_US
dc.identifier.endpage291tr_TR
dc.identifier.issn0143-4179
dc.identifier.issue4tr_TR
dc.identifier.pubmed20227110tr_TR
dc.identifier.scopus2-s2.0-77953536456tr_TR
dc.identifier.startpage285tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.npep.2010.02.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0143417910000260
dc.identifier.urihttp://hdl.handle.net/11452/24096
dc.identifier.volume44tr_TR
dc.identifier.wos000279098900001tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.journalNeuropeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGLP-1en_US
dc.subjectSeizureen_US
dc.subjectOpen fielden_US
dc.subjectElevated plus mazeen_US
dc.subjectArginine vasopressinen_US
dc.subjectNitric oxideen_US
dc.subjectRaten_US
dc.subjectHippocampal plasticityen_US
dc.subjectReceptoren_US
dc.subjectBrainen_US
dc.subjectNeuronsen_US
dc.subjectVasopressinen_US
dc.subjectExpressionen_US
dc.subjectExendin-4en_US
dc.subjectReleaseen_US
dc.subjectNucleien_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.emtreeArgipressinen_US
dc.subject.emtreeGlucagon like peptideen_US
dc.subject.emtreeN(g) nitroarginine methyl esteren_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreePilocarpineen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeVasopressin receptor antagonisten_US
dc.subject.emtreeAnimal behavioren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnxietyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug administration routeen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeExploratory behavioren_US
dc.subject.emtreeLocomotionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMaze testen_US
dc.subject.emtreeNeuroprotectionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOpen field behavioren_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeResponse timeen_US
dc.subject.emtreeSeizureen_US
dc.subject.emtreeTranquilizing activityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-anxiety agentsen_US
dc.subject.meshAnticonvulsantsen_US
dc.subject.meshAnxietyen_US
dc.subject.meshExploratory behavioren_US
dc.subject.meshGlucagon-like peptide 1en_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor activityen_US
dc.subject.meshMuscarinic agonistsen_US
dc.subject.meshNG-nitroarginine methyl esteren_US
dc.subject.meshNitric oxideen_US
dc.subject.meshNitric oxide synthase type Ien_US
dc.subject.meshPilocarpineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReceptors, vasopressinen_US
dc.subject.meshSeizuresen_US
dc.subject.meshVasopressinsen_US
dc.subject.scopusGlucagon-Like Peptide-1 Receptor; Gastric Inhibitory Polypeptide; Exendin (9-39)en_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosNeurosciencesen_US
dc.titleEffects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in raten_US
dc.typeArticle
dc.wos.quartileQ3en_US

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