Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis
dc.contributor.author | Eralp, Oya İnan | |
dc.contributor.author | Tvarijonaviciute, Asta | |
dc.contributor.author | Ceron, J. Jose | |
dc.contributor.buuauthor | Kocatürk, Meriç | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.buuauthor | Özyiğit, Musa Özgür | |
dc.contributor.buuauthor | Yılmaz, Zeki | |
dc.contributor.buuauthor | Kahraman, Müjdat Müfit | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-9836-0749 | tr_TR |
dc.contributor.orcid | 0000-0003-2918-5064 | tr_TR |
dc.contributor.researcherid | AAH-2873-2021 | tr_TR |
dc.contributor.researcherid | AAR-6478-2021 | tr_TR |
dc.contributor.researcherid | A-9637-2008 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.researcherid | V-5578-2017 | tr_TR |
dc.contributor.scopusid | 36437200800 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.contributor.scopusid | 6507338060 | tr_TR |
dc.contributor.scopusid | 35944810500 | tr_TR |
dc.contributor.scopusid | 6701778876 | tr_TR |
dc.date.accessioned | 2023-09-27T07:21:11Z | |
dc.date.available | 2023-09-27T07:21:11Z | |
dc.date.issued | 2016-08-17 | |
dc.description.abstract | The aim of the present study was to investigate effects of intravenous (i.v.) choline treatment on serum matrix metalloproteinases (MMP), MMP tissue inhibitors (TIMP) and immunoglobulins (Igs), and to determine if there were relations between serum MMPs/TIMPs and C-reactive protein (CRP) (as a marker of the acute phase response), immunoglobulin G and M (IgG and IgM) (as a maker of the Ig responses) and markers of organ damage such as muscular damage (creatine phosphokinase, [CPK]), liver damage (alanine aminotransferase [ALT]) and renal dysfunction (blood urea nitrogen [BUN] and creatinine, [Cr]) in dogs with endotoxemia. Healthy dogs (n = 24) were randomized to Saline, Choline (C), Lipopolysaccharide (LPS), and LPS + C groups and received 0.9% NaCl (5 mL/i.v.), choline chloride (20 mg/kg/i.v.), LPS (0.02 mg/kg/i.v.) and LPS (0.02 mg/kg/i.v.) plus choline chloride (20 mg/kg/i.v.), respectively. Serum MMPs and TIMPs concentrations were analyzed by commercial ELISA kits. MMP and TIMP increased at 1-48 h (P < 0.05), whereas IgG and IgM decreased at 24-48 h in LPS group, compared to their baselines. Choline treatment reduced changes in serum MMPs, TIMPs and markers of organ damage, and prevented the hypoimmunoglobulinemia in LPS + C. MMPs and TIMPs were correlated positively (P < 0.05) with serum CRP, CPK, ALT, BUN and Cr, but not with serum Igs. Our findings suggest that the serum MMPs, TIMPs and Igs are involved in the pathophysiology of endotoxemia, and MMPs and TIMPs are correlated with the acute phase reaction and multi-organ failure. In addition, we demonstrated a direct effect of choline administration in decreasing serum MMPs and TIMPs, and preserving serum Igs in the course of endotoxemia. | en_US |
dc.identifier.citation | Kocatürk, M. vd. (2016). "Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis". Veterinary Immunology and Immunopathology, 180, 9-14. | en_US |
dc.identifier.endpage | 14 | tr_TR |
dc.identifier.issn | 0165-2427 | |
dc.identifier.issn | 1873-2534 | |
dc.identifier.pubmed | 27692098 | tr_TR |
dc.identifier.scopus | 2-s2.0-84989947616 | tr_TR |
dc.identifier.startpage | 9 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.vetimm.2016.08.011 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0165242716301581 | |
dc.identifier.uri | http://hdl.handle.net/11452/34079 | |
dc.identifier.volume | 180 | tr_TR |
dc.identifier.wos | 000385328400002 | tr_TR |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.bap | KUAP - (V) - 2013/9 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Veterinary Immunology and Immunopathology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.relation.tubitak | TOVAG-1090660 | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Immunology | en_US |
dc.subject | Veterinary sciences | en_US |
dc.subject | Endotoxemia | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Choline | en_US |
dc.subject | Matrix metalloproteinase | en_US |
dc.subject | Immunoglobulin | en_US |
dc.subject | Dog | en_US |
dc.subject | Antiinflammatory pathway | en_US |
dc.subject | Endotoxin | en_US |
dc.subject | Dogs | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | C reactive protein | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Collagenase 3 | en_US |
dc.subject.emtree | Creatine kinase | en_US |
dc.subject.emtree | Creatinine | en_US |
dc.subject.emtree | Gelatinase A | en_US |
dc.subject.emtree | Gelatinase B | en_US |
dc.subject.emtree | Immunoglobulin | en_US |
dc.subject.emtree | Immunoglobulin G | en_US |
dc.subject.emtree | Immunoglobulin M | en_US |
dc.subject.emtree | Interstitial collagenase | en_US |
dc.subject.emtree | Matrix metalloproteinase | en_US |
dc.subject.emtree | Nitrogen | en_US |
dc.subject.emtree | Stromelysin | en_US |
dc.subject.emtree | Tissue inhibitor of metalloproteinase | en_US |
dc.subject.emtree | Tissue inhibitor of metalloproteinase 1 | en_US |
dc.subject.emtree | Tissue inhibitor of metalloproteinase 2 | en_US |
dc.subject.emtree | Urea | en_US |
dc.subject.emtree | C reactive protein | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Immunoglobulin G | en_US |
dc.subject.emtree | Immunoglobulin M | en_US |
dc.subject.emtree | Matrix metalloproteinase | en_US |
dc.subject.emtree | Tissue inhibitor of metalloproteinase | en_US |
dc.subject.emtree | Acute phase response | en_US |
dc.subject.emtree | Alanine aminotransferase blood level | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Creatine kinase blood level | en_US |
dc.subject.emtree | ELISA kit | en_US |
dc.subject.emtree | Enzyme blood level | en_US |
dc.subject.emtree | Enzyme linked immunosorbent assay | en_US |
dc.subject.emtree | Experimental endotoxemia | en_US |
dc.subject.emtree | Immunoglobulin blood level | en_US |
dc.subject.emtree | Immunoglobulin deficiency | en_US |
dc.subject.emtree | Liver injury | en_US |
dc.subject.emtree | Molecular pathology | en_US |
dc.subject.emtree | Muscle injury | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Single drug dose | en_US |
dc.subject.emtree | Urea nitrogen blood level | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Disease model | en_US |
dc.subject.emtree | Dog | en_US |
dc.subject.emtree | Endotoxemia | en_US |
dc.subject.emtree | Immunology | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | C-reactive protein | en_US |
dc.subject.mesh | Choline | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endotoxemia | en_US |
dc.subject.mesh | Immunoglobulin G | en_US |
dc.subject.mesh | Immunoglobulin M | en_US |
dc.subject.mesh | Matrix metalloproteinases | en_US |
dc.subject.mesh | Tissue inhibitor of metalloproteinases | en_US |
dc.subject.scopus | Gelatinase B; Tissue Inhibitor Of Metalloproteinase 1; Sepsis | en_US |
dc.subject.wos | Immunology | en_US |
dc.subject.wos | Veterinary sciences | en_US |
dc.title | Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 (Immunology) | en_US |
dc.wos.quartile | Q1 (Veterinary sciences) | en_US |
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