BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer
dc.contributor.buuauthor | Ertürk, Elif | |
dc.contributor.buuauthor | Çeçener, Gülşah | |
dc.contributor.buuauthor | Tezcan, Gülçin | |
dc.contributor.buuauthor | Egeli, Ünal | |
dc.contributor.buuauthor | Tunca, Berrin | |
dc.contributor.buuauthor | Gökgöz, Şehsuvar | |
dc.contributor.buuauthor | Tolunay, Şahsine | |
dc.contributor.buuauthor | Taşdelen, İsmet | |
dc.contributor.department | Uludağ Üniversitesi/Sağlık Meslek Yükseokulu/Tıbbi Laboratuvar Teknikleri Programı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-7668-796X | tr_TR |
dc.contributor.orcid | 0000-0002-3820-424X | tr_TR |
dc.contributor.orcid | 0000-0002-5956-8755 | tr_TR |
dc.contributor.orcid | 0000-0001-7904-883X | tr_TR |
dc.contributor.orcid | 0000-0002-1619-6680 | tr_TR |
dc.contributor.orcid | 0000-0003-1394-2630 | tr_TR |
dc.contributor.orcid | 0000-0002-9038-0515 | tr_TR |
dc.contributor.researcherid | AAK-3371-2021 | tr_TR |
dc.contributor.researcherid | AAP-9988-2020 | tr_TR |
dc.contributor.researcherid | AAH-3843-2020 | tr_TR |
dc.contributor.researcherid | AAH-1420-2021 | tr_TR |
dc.contributor.researcherid | ABI-6078-2020 | tr_TR |
dc.contributor.researcherid | EXK-4525-2022 | tr_TR |
dc.contributor.researcherid | AAI-1612-2021 | tr_TR |
dc.contributor.researcherid | EBN-1186-2022 | tr_TR |
dc.contributor.scopusid | 50261655300 | tr_TR |
dc.contributor.scopusid | 6508156530 | tr_TR |
dc.contributor.scopusid | 25650627600 | tr_TR |
dc.contributor.scopusid | 55665145000 | tr_TR |
dc.contributor.scopusid | 6602965754 | tr_TR |
dc.contributor.scopusid | 6603238737 | tr_TR |
dc.contributor.scopusid | 6602604390 | tr_TR |
dc.contributor.scopusid | 9637821500 | tr_TR |
dc.date.accessioned | 2022-09-09T12:12:56Z | |
dc.date.available | 2022-09-09T12:12:56Z | |
dc.date.issued | 2015-02-10 | |
dc.description.abstract | Triple negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer (BC). Over the recent years, miRNA expression studies have been providing certain detailed overview that aberrant expression of miRNAs is associated with TNBC. Although TNBC tumors are strongly connected with loss of function of BRCA genes, there is no knowledge about the effect of BRCA mutation status on miRNA expressions in TNBC cases. The aims of this study were to evaluate the expression profile of miRNAs that plays role in TNBC progression and the role of BRCA mutations in their regulation. The expression level of BC associated 13 miRNAs was analyzed in 7 BRCA mutations positive, 6 BRCA mutations negative TNBC cases and 20 non-tumoral tissues using RT-PCR. According to RT2 Profiler PCR Array Data Analysis, let-7a expression was 4.67 fold reduced in TNBCs as compared to normal tissues (P = 0.031). In addition, miR-200c expression was 5.75 fold reduced in BRCA mutation positive TNBC tumors (P = 0.005). Analysis revealed a negative correlation between miR-200c and VEGFA expressions (r = -468). Thus, miR-200c may be involved in invasion and metastasis in TNBC cases with BRCA mutation. In this study we provide the knowledge on the first report of association between microRNA-200c and BRCA mutations in TNBC. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for TNBC treatment and new directions for the development of anticancer drugs. | en_US |
dc.identifier.citation | Ertürk, E. vd. (2015). "BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer". Gene, 556(2), 163-169. | en_US |
dc.identifier.endpage | 169 | tr_TR |
dc.identifier.issn | 0378-1119 | |
dc.identifier.issn | 1879-0038 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 25445393 | tr_TR |
dc.identifier.scopus | 2-s2.0-84919872180 | tr_TR |
dc.identifier.startpage | 163 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.gene.2014.11.047 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378111914013249 | |
dc.identifier.uri | http://hdl.handle.net/11452/28614 | |
dc.identifier.volume | 556 | tr_TR |
dc.identifier.wos | 000349589800012 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.bap | UAP(T)-2011/1 | tr_TR |
dc.relation.journal | Gene | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | BRCA1/2 gene mutations | en_US |
dc.subject | MicroRNA | en_US |
dc.subject | MiR-200c | en_US |
dc.subject | Triple negative breast cancer | en_US |
dc.subject | Epithelial-mesenchymal transition | en_US |
dc.subject | Down-regulation | en_US |
dc.subject | Ovarian-cancer | en_US |
dc.subject | Feedback loop | en_US |
dc.subject | Family | en_US |
dc.subject | Zeb1 | en_US |
dc.subject | MicroRNA-200c | en_US |
dc.subject | Progression | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Resistance | en_US |
dc.subject.emtree | BRCA1 protein | en_US |
dc.subject.emtree | BRCA1 protein, human | en_US |
dc.subject.emtree | BRCA2 protein | en_US |
dc.subject.emtree | BRCA2 protein, human | en_US |
dc.subject.emtree | MicroRNA | en_US |
dc.subject.emtree | Mırn200 microrna, human | en_US |
dc.subject.emtree | Mirnlet7 microRNA, human | en_US |
dc.subject.emtree | Vasculotropin A | en_US |
dc.subject.emtree | VEGFA protein, human | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cancer growth | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene expression profiling | en_US |
dc.subject.emtree | Gene expression regulation | en_US |
dc.subject.emtree | Gene mutation | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Let 7a gene | en_US |
dc.subject.emtree | Oncogene | en_US |
dc.subject.emtree | Reverse transcription polymerase chain reaction | en_US |
dc.subject.emtree | Triple negative breast cancer | en_US |
dc.subject.emtree | Tumor invasion | en_US |
dc.subject.emtree | VEGFA gene | en_US |
dc.subject.emtree | Disease course | en_US |
dc.subject.emtree | Genetics | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Mutation | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Triple negative breast cancer | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | BRCA1 protein | en_US |
dc.subject.mesh | BRCA2 protein | en_US |
dc.subject.mesh | Disease progression | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene expression regulation | en_US |
dc.subject.mesh | Neoplastic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | MicroRNAs | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Mutation | en_US |
dc.subject.mesh | Triple negative breast neoplasms | en_US |
dc.subject.mesh | Vascular endothelial growth factor A | en_US |
dc.subject.scopus | Circulating Microrna; Stomach Neoplasms; Breast Neoplasms | en_US |
dc.subject.wos | Genetics & Heredity | en_US |
dc.title | BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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