Evaluation of melatonin and prostaglandin El combination on necrotizing enterocolitis model in neonatal rats

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dc.contributor.authorÇekmez, Ferhat
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorTayman, Cüneyt
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorUysal, Sema
dc.contributor.authorTunç, Turan
dc.contributor.authorSarıcı, Serdar Ümit
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.date.accessioned2022-10-21T09:28:32Z
dc.date.available2022-10-21T09:28:32Z
dc.date.issued2013-06-10
dc.description.abstractBackground: Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in newborn infants but up to now there is no completely effective treatment for it. Objective: In order to show that a combination of melatonin and prostaglandins may be useful to save lives, we use newborn rat as a model of necrotizing enterocolitis to test the hypothesis of using the combination therapy might have more potential effect on mucosal cytoprotection and healing. Patients and methods: A total of 60 newborn pups from 5 time-mated Sprague-Dawley pregnant rats were divided equally into 5 groups as follows: NEC (subjected to NEC), NEC + Melatonin, NEC + Prostaglandin, NEC + Prostaglandin + Melatonin and control. These animals were fed with hyperosmolar formula 3 times daily and subjected to 100% CO2 inhalation for 10 min, +4 degrees C cold exposure for 5 min, and 97% O-2 for 5 min twice daily to induce NEC. This procedure was applied to the pups for 3 days. Results: The macroscopic scoring, intestinal injury scoring and apoptosis index scoring were all found to be significantly lower in NEC + Prostaglandin + Melatonin group compared with NEC group. Anti-oxidant enzyme activities were significantly higher, whereas lipid peroxidation was significantly lower in NEC + Prostaglandin + Melatonin group compared with NEC group. Conclusion: This combination therapy showed cytoprotective and healing effects on mucosa in the intestinal tissue of rat pups in necrotizing enterocolitis model. Therefore, this therapy might also show benefit in preterm infants with NEC. After confirmation of this data by other clinical and experimental studies, it may be a novel therapeutic option for the prevention of NEC in preterm infants.en_US
dc.identifier.citationÇekmez, F. vd. (2013). "Evaluation of melatonin and prostaglandin El combination on necrotizing enterocolitis model in neonatal rats". Regulatory Peptides, 184, 121-125.en_US
dc.identifier.endpage125tr_TR
dc.identifier.issnhttps://pubmed.ncbi.nlm.nih.gov/23524022/
dc.identifier.issn0167-0115
dc.identifier.issn1873-1686
dc.identifier.pubmed23524022tr_TR
dc.identifier.scopus2-s2.0-84877066418tr_TR
dc.identifier.startpage121tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2013.03.016
dc.identifier.urihttp://hdl.handle.net/11452/29177
dc.identifier.volume184tr_TR
dc.identifier.wos000320220700017
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalRegulatory Peptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectPhysiologyen_US
dc.subjectMelatoninen_US
dc.subjectProstaglandin E1en_US
dc.subjectNECen_US
dc.subjectPreterm infanten_US
dc.subjectOxidative stressen_US
dc.subjectMisoprostolen_US
dc.subjectMulticenteren_US
dc.subjectReductionen_US
dc.subjectApoptosisen_US
dc.subject.emtreeCarbon dioxideen_US
dc.subject.emtreeLipiden_US
dc.subject.emtreeMelatoninen_US
dc.subject.emtreeProstaglandin E1en_US
dc.subject.emtreeProstavasinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCarbon dioxide breathingen_US
dc.subject.emtreeCell protectionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeHealingen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeIntestine injuryen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeNecrotizing enterocolitisen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScoring systemen_US
dc.subject.meshAlprostadilen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, newbornen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshEnterocolitis, necrotizingen_US
dc.subject.meshFemaleen_US
dc.subject.meshMelatoninen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.scopusInterleukin-21; Checkpoint; Immunotherapyen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosPhysiologyen_US
dc.titleEvaluation of melatonin and prostaglandin El combination on necrotizing enterocolitis model in neonatal ratsen_US
dc.typeArticle

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