AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
dc.contributor.buuauthor | Gülten, Tuna | |
dc.contributor.buuauthor | Yakut, Tahsin | |
dc.contributor.buuauthor | Karkucak, Mutlu | |
dc.contributor.buuauthor | Baytan, Birol | |
dc.contributor.buuauthor | Güneş, Adalet Meral | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Hematoloji Anabilim Dalı. | tr_TR |
dc.contributor.scopusid | 6505944216 | tr_TR |
dc.contributor.scopusid | 6602802424 | tr_TR |
dc.contributor.scopusid | 35388323500 | tr_TR |
dc.contributor.scopusid | 6506622162 | tr_TR |
dc.contributor.scopusid | 24072843300 | tr_TR |
dc.date.accessioned | 2022-01-12T12:35:45Z | |
dc.date.available | 2022-01-12T12:35:45Z | |
dc.date.issued | 2009 | |
dc.description.abstract | We report a case of childhood acute lymphoblastic leukemia (ALL) with both acute myeloid leukemia 1 (AML1) amplification and 17q25 deletion. AML1 gene is located on 21q22 and encodes a transcription factor. AML1 amplification is a common finding in childhood ALL, and itis observed as an increase in gene copy number by the FISH analysis. The mechanism of AML1 amplification is not associated with AML1 gene mutations. The 17q25 is a gene-rich chromosomal location and distinct abnormalities of this region have been observed in previous cases of different kinds of leukemia. Deletion of the 17q25 region has been reported in two leukemia patients. Septin 9 (SEPT9) and survivin genes are located on 17q25. High expression of these genes and AML1 amplification are regarded as markers in tumorigenesis and disease progression; however, more data are needed for accurate prognostic evaluation. | en_US |
dc.identifier.citation | Gülten, T. vd. (2009). "AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia". Journal of Clinical Laboratory Analysis, 23(6), 368-371. | en_US |
dc.identifier.endpage | 371 | tr_TR |
dc.identifier.issn | 0887-8013 | |
dc.identifier.issue | 6 | tr_TR |
dc.identifier.pubmed | 19927343 | tr_TR |
dc.identifier.scopus | 2-s2.0-73249144849 | tr_TR |
dc.identifier.startpage | 368 | tr_TR |
dc.identifier.uri | https://doi.org/10.1002/jcla.20343 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/jcla.20343 | |
dc.identifier.uri | http://hdl.handle.net/11452/24045 | |
dc.identifier.volume | 23 | tr_TR |
dc.identifier.wos | 000272672600004 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Journal of Clinical Laboratory Analysis | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 17q25 | en_US |
dc.subject | Aberration | en_US |
dc.subject | Acute lymphoblastic leukemia | en_US |
dc.subject | AML1 amplification | en_US |
dc.subject | SEPT9 | en_US |
dc.subject | Abnormalities | en_US |
dc.subject | Genes | en_US |
dc.subject | Medical laboratory technology | en_US |
dc.subject.emtree | Transcription factor | en_US |
dc.subject.emtree | Acute lymphoblastic leukemia | en_US |
dc.subject.emtree | Adolescent | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cancer patient | en_US |
dc.subject.emtree | Carcinogenesis | en_US |
dc.subject.emtree | Case report | en_US |
dc.subject.emtree | Chromosome 17q | en_US |
dc.subject.emtree | Chromosome deletion | en_US |
dc.subject.emtree | Disease course | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene amplification | en_US |
dc.subject.emtree | Gene expression | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Chromosome deletion | en_US |
dc.subject.mesh | Chromosomes, human, pair 17 | en_US |
dc.subject.mesh | Core binding factor alpha 2 subunit | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene amplification | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | In situ hybridization, fluorescence | en_US |
dc.subject.mesh | Karyotyping | en_US |
dc.subject.mesh | Metaphase | en_US |
dc.subject.mesh | Precursor cell lymphoblastic leukemia-lymphoma | en_US |
dc.subject.scopus | Acute Lymphoblastic Leukemia; Chromosome 21; Pre B Lymphocyte | en_US |
dc.subject.wos | Medical laboratory technology | en_US |
dc.title | AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |