Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis
dc.contributor.buuauthor | Kıyıcı, Murat | |
dc.contributor.buuauthor | Gürel, Selim | |
dc.contributor.buuauthor | Budak, Ferah | |
dc.contributor.buuauthor | Dolar, Enver | |
dc.contributor.buuauthor | Gülten, Macit | |
dc.contributor.buuauthor | Nak, Selim Giray | |
dc.contributor.buuauthor | Memik, Faruk | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Bilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-3208-6211 | tr_TR |
dc.contributor.researcherid | AAG-9177-2021 | tr_TR |
dc.contributor.researcherid | AAI-4213-2021 | tr_TR |
dc.contributor.researcherid | F-4657-2014 | tr_TR |
dc.contributor.scopusid | 6507627491 | tr_TR |
dc.contributor.scopusid | 7003706434 | tr_TR |
dc.contributor.scopusid | 6701913697 | tr_TR |
dc.contributor.scopusid | 6602075084 | tr_TR |
dc.contributor.scopusid | 6603629209 | tr_TR |
dc.contributor.scopusid | 6603336505 | tr_TR |
dc.contributor.scopusid | 6701813462 | tr_TR |
dc.date.accessioned | 2022-04-26T05:43:46Z | |
dc.date.available | 2022-04-26T05:43:46Z | |
dc.date.issued | 2003-10 | |
dc.description.abstract | Background Apoptosis may be defined as programmed cell death. It is involved in the normal development and homeostasis of tissues in multicellular organisms. An increased or decreased rate of apoptosis may lead to a range of diseases. Fas antigen is a cell-surface receptor that induces apoptotic pathways when treated with Fas ligand or anti-Fas antibody. There is increasing evidence that apoptosis plays an important role in the immunopathogenesis of chronic viral hepatitis, in which the Fas antigen-Fas ligand pathway is particularly involved. Methods Fas antigen expression and apoptosis (apoptotic index) were assayed using flow cytometry in the hepatocytes of 27 patients with chronic viral hepatitis. Histopathological activity, scored by Knodell's histological activity index, other histopathological parameters, serum transaminase values and patient age were then compared with apoptotic index and Fas antigen expression. Results Apoptosis and Fas antigen expression in hepatocytes were correlated closely with histological activity (grade) Of chronic viral hepatitis, but there were no correlations with histological stage, patient age or serum transaminase levels. Conclusion Apoptosis and its triggering molecule, Fas antigen, induce mechanisms that appear to be associated with the pathogenesis of chronic viral hepatitis. | en_US |
dc.identifier.citation | Kıyıcı, M. vd. (2003). “Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis”. European Journal of Gastroenterology and Hepatology, 15(10), 1079-1084. | en_US |
dc.identifier.endpage | 1084 | tr_TR |
dc.identifier.issn | 0954-691X | |
dc.identifier.issue | 10 | tr_TR |
dc.identifier.pubmed | 14501615 | tr_TR |
dc.identifier.scopus | 2-s2.0-0142107398 | tr_TR |
dc.identifier.startpage | 1079 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/00042737-200310000-00003 | |
dc.identifier.uri | https://journals.lww.com/eurojgh/Fulltext/2003/10000/Fas_antigen__CD95__expression_and_apoptosis_in.3.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/26063 | |
dc.identifier.volume | 15 | tr_TR |
dc.identifier.wos | 000185872800003 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams and Wilkins | en_US |
dc.relation.journal | European Journal of Gastroenterology and Hepatology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Gastroenterology and hepatology | en_US |
dc.subject | Chronic viral hepatitis | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Fas antigen | en_US |
dc.subject | Receptor superfamily | en_US |
dc.subject | Cell-death | en_US |
dc.subject | Ligand | en_US |
dc.subject | Involvement | en_US |
dc.subject.emtree | Adolescent | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Age | en_US |
dc.subject.emtree | Aminotransferase blood level | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Correlation analysis | en_US |
dc.subject.emtree | Enzyme assay | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Flow cytometry | en_US |
dc.subject.emtree | Hepatitis B virus | en_US |
dc.subject.emtree | Histopathology | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Liver cell | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Virus hepatitis | en_US |
dc.subject.emtree | Aminotransferase | en_US |
dc.subject.emtree | Fas antigen | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Antigens, CD95 | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | DNA fragmentation | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Flow cytometry | en_US |
dc.subject.mesh | Hepatitis B, chronic | en_US |
dc.subject.mesh | Hepatitis C, chronic | en_US |
dc.subject.mesh | Hepatocytes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Transaminases | en_US |
dc.subject.scopus | Liver Cell; Metabolism; Markers | en_US |
dc.subject.wos | Gastroenterology and hepatology | en_US |
dc.title | Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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