Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid
dc.contributor.author | Özel, Mustafa Zafer | |
dc.contributor.buuauthor | Çelikler, Serap | |
dc.contributor.buuauthor | Taş, Sibel | |
dc.contributor.buuauthor | Ziyanok, Sedef Ayvalık | |
dc.contributor.buuauthor | Vatan, Özgür | |
dc.contributor.buuauthor | Yıldız, Gamze | |
dc.contributor.department | Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-4177-3478 | tr_TR |
dc.contributor.orcid | 0000-0002-7687-3284 | tr_TR |
dc.contributor.researcherid | AAH-2767-2021 | tr_TR |
dc.contributor.researcherid | ABE-6873-2020 | tr_TR |
dc.contributor.researcherid | O-7508-2015 | tr_TR |
dc.contributor.researcherid | A-9944-2010 | tr_TR |
dc.contributor.scopusid | 8234554800 | tr_TR |
dc.contributor.scopusid | 7004343411 | tr_TR |
dc.contributor.scopusid | 15128398000 | tr_TR |
dc.contributor.scopusid | 16235098100 | tr_TR |
dc.contributor.scopusid | 6701743065 | tr_TR |
dc.date.accessioned | 2024-02-20T06:28:16Z | |
dc.date.available | 2024-02-20T06:28:16Z | |
dc.date.issued | 2014-03 | |
dc.description.abstract | The presence of chromosomal damage in bone marrow cells affected by several diseases such as thyroid, cancer etc., was detected by the micronucleus (MN) assay. The present study was designed to evaluate: i) volatile components of Ulva rigida, ii) effects of hypothyroidism on bone marrow MN frequency, iii) effects of oral administration of Ulva rigida ethanolic extract (URE) on MN frequency produced by hypothyroidism, and iv) thyroid hormone levels in normal and 6-n-Propylthiouracil (PTU)-induced hypothyroid rats. The volatile components of Ulva rigida was studied using a direct thermal desorption (DTD) technique with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOF/MS). URE administration was of no significant impact on thyroid hormone levels in control group, while PTU administration decreased thyroid hormone levels compared to control group (p < 0.001). Moreover, URE supplementation resulted in a significant decrease in MN frequency in each thyroid group (p < 0.0001). This is the first in vivo study that shows the strong antigenotoxic and protective effect of URE against the genotoxicity produced by hypothyroidism. | en_US |
dc.identifier.citation | Çelikler, S. vd. (2014). "Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid". Acta Biologica Hungarica, 65(1), 13-26. | en_US |
dc.identifier.doi | https://doi.org/10.1556/ABiol.65.2014.1.2 | en_US |
dc.identifier.eissn | 1588-256X | |
dc.identifier.endpage | 26 | tr_TR |
dc.identifier.issn | 0236-5383 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 24561891 | tr_TR |
dc.identifier.scopus | 2-s2.0-84896811476 | tr_TR |
dc.identifier.startpage | 13 | tr_TR |
dc.identifier.uri | https://akjournals.com/view/journals/018/65/1/article-p13.xml | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/39858 | en_US |
dc.identifier.volume | 65 | tr_TR |
dc.identifier.wos | 000332009000002 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Akademiai Kiado Zrt | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Acta Biologica Hungarica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antigenotoxic effect | en_US |
dc.subject | Volatile compounds | en_US |
dc.subject | Micronucleus | en_US |
dc.subject | Thyroid | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Ulva rigida | en_US |
dc.subject | Life sciences & biomedicine - other topics | en_US |
dc.subject | Antigenotoxic effect | en_US |
dc.subject | Micronucleus | en_US |
dc.subject | Volatile compounds | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Thyroid | en_US |
dc.subject | Ulva rigida | en_US |
dc.subject | Sister-chromatid exchange | en_US |
dc.subject | Direct thermal-desorption | en_US |
dc.subject | Graves-diseasestress | en_US |
dc.subject | Oxidative dna-damage | en_US |
dc.subject | Thyroid-hormone | en_US |
dc.subject | Lipid-peroxidation | en_US |
dc.subject | Serum paraoxonase | en_US |
dc.subject | Peripheral-blood | en_US |
dc.subject | Taurine supplementation | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Chromosome damage | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Desorption | en_US |
dc.subject.emtree | Dna damage | en_US |
dc.subject.emtree | Gas chromatography | en_US |
dc.subject.emtree | Genotoxicity | en_US |
dc.subject.emtree | Hypothyroidism | en_US |
dc.subject.emtree | In vivo study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Micronucleus test | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Time of flight mass spectrometry | en_US |
dc.subject.emtree | Natural product | en_US |
dc.subject.emtree | Propylthiouracil | en_US |
dc.subject.emtree | Thyroid hormone | en_US |
dc.subject.emtree | Ulva rigida extract | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell nucleus | en_US |
dc.subject.mesh | Dna damage | en_US |
dc.subject.mesh | Drug evaluation, preclinical | en_US |
dc.subject.mesh | Hypothyroidism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Micronucleus tests | en_US |
dc.subject.mesh | Phytotherapy | en_US |
dc.subject.mesh | Plant extracts | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.mesh | Ulva | en_US |
dc.subject.scopus | Hyperthyroidism; Propylthiouracil; Oxidative Stress | en_US |
dc.subject.wos | Biology | en_US |
dc.title | Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid | en_US |
dc.type | Article | en_US |
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