Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients

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Date

2010-06

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Wiley

Abstract

Aim: The aim of the present study was to assess the efficacy and safety of colistimethate sodium therapy in multidrug-resistant nosocomial infections caused by Pseudomonas aeruginosa or Acinetobacter baumannii in neonates and children. Methods: Pediatric patients hospitalized at the Uludag University Hospital who had nosocomial infections caused by multidrug-resistant P. aeruginosa or A. baumannii, were enrolled in the study. Colistimethate sodium at a dosage of 50-75 x 103 U/kg per day was given i.v. divided into three doses. Results: Fifteen patients received 17 courses of colistimethate sodium for the following infections: ventilator-associated pneumonia (n = 14), catheter-related sepsis (n = 1) and skin and soft-tissue infection (n = 2). The mean age of patients was 53.2 + 74.7 months (range, 8 days-15 years) and 60% were male. Mortality was 26.6%. Conclusion: Colistimethate sodium appears to be safe and effective for the treatment of severe infections caused by multidrug-resistant P. aeruginosa or A. baumannii in pediatric patients.

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Keywords

Acinetobacter baumannii, Children, Colistimethate sodium, Nosocomial infection, Pseudomonas aeruginosa, Ventilator-associated pneumonia, Intensive-care-unit, Pseudomonas-aeruginosa, Intravenous colistin, Nosocomial infections, Risk-factors, Acinetobacter, Pediatrics

Citation

Çelebi, S. vd. (2010). "Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients". Pediatrics International, 52(3), 410-414.