Publication:
Cerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitis

No Thumbnail Available

Date

1994

Authors

Akalın, Halis
Akdış, A.C.
Mıstık, Reşit
Helvacı, Safiye
Kılıçturgay, Kaya

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Scandinavian University Press

Research Projects

Organizational Units

Journal Issue

Abstract

The levels of interleukin-1 beta, IL-1 receptor antagonist and tumor necrosis factor-alpha (TNF-alpha) were analyzed in 19 cases of tuberculous, 14 cases of viral, and 22 cases of acute bacterial meningitis, and in 18 control: subjects, 20 patients (91%) with acute bacterial and 8(42%) with tuberculous meningitis had detectable amounts of TNF-alpha in the initial cerebrospinal fluid (CSF) sample (mean 1044 +/- 131 pg/ml, range 95-1950, and mean 61 +/- 23 pg/ml, range 25-300, respectively), whereas TNF-alpha was not detectable in any of the patients with viral meningitis or in any of the control subjects. IL-1 beta levels were 767 +/- 110 pg/ml (185-2000) in acute bacterial, 345 +/- 63 pg/ml (50-670) in tuberculous, 257 +/- 70 pg/ml (20-700) in viral meningitis, and 37 +/- 4 pg/ml (10-68) in control subjects. Il-1 receptor antagonist concentrations were significantly elevated in all meningitis groups, without significant differences between the groups. Il-1 receptor antagonist levels were 2487 +/- 62 pg/ml (2250-2950) in acute bacterial, 2216 +/- 82 pg/ml (1350-2550) in tuberculous and 1985 +/- 92 pg/ml (650-2500) in viral meningitis, and 154 +/- 26 pg/ml (20-245) in control CSF samples. A positive correlation was found between TNF and IL-1 beta levels (p < 0.01), and TNF levels and conscious state (p < 0.05). The ratio of concentrations of IL-1 receptor antagonist to IL-1 beta was 3.2 in acute bacterial meningitis, 6.9 in tuberculous meningitis and 8.3 in viral meningitis. This ratio was significantly different between the acute bacterial meningitis group and the other groups (p < 0.01), which indicates that the balance between cytokines and antagonists is of importance for the pathogenicity and diagnosis of central nervous system infections.

Description

Keywords

Interleukin-1 production, Meningeal inflammation, Cytokines, Il-1, Cachectin, Association, Il-1-beta, Children, Disease, Serum

Citation

Akalın, H. vd. (1994). ''Cerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitis''. Scandinavian Journal of Infectious Diseases", 26(6), 667-674.

0

Views

0

Downloads

Search on Google Scholar