Publication:
Cerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitis

dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorAkdış, A.C.
dc.contributor.buuauthorMıstık, Reşit
dc.contributor.buuauthorHelvacı, Safiye
dc.contributor.buuauthorKılıçturgay, Kaya
dc.contributor.departmentTıp Fakültesi
dc.contributor.scopusid57207553671
dc.contributor.scopusid6602564624
dc.contributor.scopusid6602103491
dc.contributor.scopusid6701350394
dc.date.accessioned2021-06-21T10:00:23Z
dc.date.available2021-06-21T10:00:23Z
dc.date.issued1994
dc.description.abstractThe levels of interleukin-1 beta, IL-1 receptor antagonist and tumor necrosis factor-alpha (TNF-alpha) were analyzed in 19 cases of tuberculous, 14 cases of viral, and 22 cases of acute bacterial meningitis, and in 18 control: subjects, 20 patients (91%) with acute bacterial and 8(42%) with tuberculous meningitis had detectable amounts of TNF-alpha in the initial cerebrospinal fluid (CSF) sample (mean 1044 +/- 131 pg/ml, range 95-1950, and mean 61 +/- 23 pg/ml, range 25-300, respectively), whereas TNF-alpha was not detectable in any of the patients with viral meningitis or in any of the control subjects. IL-1 beta levels were 767 +/- 110 pg/ml (185-2000) in acute bacterial, 345 +/- 63 pg/ml (50-670) in tuberculous, 257 +/- 70 pg/ml (20-700) in viral meningitis, and 37 +/- 4 pg/ml (10-68) in control subjects. Il-1 receptor antagonist concentrations were significantly elevated in all meningitis groups, without significant differences between the groups. Il-1 receptor antagonist levels were 2487 +/- 62 pg/ml (2250-2950) in acute bacterial, 2216 +/- 82 pg/ml (1350-2550) in tuberculous and 1985 +/- 92 pg/ml (650-2500) in viral meningitis, and 154 +/- 26 pg/ml (20-245) in control CSF samples. A positive correlation was found between TNF and IL-1 beta levels (p < 0.01), and TNF levels and conscious state (p < 0.05). The ratio of concentrations of IL-1 receptor antagonist to IL-1 beta was 3.2 in acute bacterial meningitis, 6.9 in tuberculous meningitis and 8.3 in viral meningitis. This ratio was significantly different between the acute bacterial meningitis group and the other groups (p < 0.01), which indicates that the balance between cytokines and antagonists is of importance for the pathogenicity and diagnosis of central nervous system infections.en_US
dc.identifier.citationAkalın, H. vd. (1994). ''Cerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitis''. Scandinavian Journal of Infectious Diseases", 26(6), 667-674.en_US
dc.identifier.endpage674
dc.identifier.issn0036-5548
dc.identifier.issue6
dc.identifier.pubmed7747089
dc.identifier.scopus2-s2.0-0028670795
dc.identifier.startpage667
dc.identifier.urihttps://doi.org/10.3109/00365549409008634
dc.identifier.urihttp://hdl.handle.net/11452/20675
dc.identifier.volume26
dc.identifier.wosA1994QD13100005
dc.indexed.pubmedPubmed
dc.indexed.wosSCIE
dc.language.isoenen_US
dc.publisherScandinavian University Pressen_US
dc.relation.journalScandinavian Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-1 productionen_US
dc.subjectMeningeal inflammationen_US
dc.subjectCytokinesen_US
dc.subjectIl-1en_US
dc.subjectCachectinen_US
dc.subjectAssociationen_US
dc.subjectIl-1-betaen_US
dc.subjectChildrenen_US
dc.subjectDiseaseen_US
dc.subjectSerumen_US
dc.subject.emtreeInterleukin 1 receptor blocking agenten_US
dc.subject.emtreeInterleukin 1betaen_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBacterial meningitisen_US
dc.subject.emtreeCerebrospinal fluiden_US
dc.subject.emtreeCerebrospinal fluid analysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePathogenicityen_US
dc.subject.emtreeTuberculous meningitisen_US
dc.subject.emtreeVirus meningitisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshComparative studyen_US
dc.subject.meshCytokinesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumanen_US
dc.subject.meshInterleukin-1en_US
dc.subject.meshMaleen_US
dc.subject.meshMeningitisen_US
dc.subject.meshBacterialen_US
dc.subject.meshMeningitisen_US
dc.subject.meshViralen_US
dc.subject.meshMiddle Ageen_US
dc.subject.meshReceptoren_US
dc.subject.meshInterleukin-1en_US
dc.subject.meshSensitivity and specificityen_US
dc.subject.meshTuberculosisen_US
dc.subject.meshMeningealen_US
dc.subject.meshTumor necrosis factoren_US
dc.subject.wosInfectious diseasesen_US
dc.titleCerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitisen_US
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesitr_TR
local.indexed.atScopus

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