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Publication A research into the effects of the government intervention on the agricultural marketing cooperatives in Turkey ‐ An alternative model(Inst Agr Econ, 1981) Başar, H.; Uludağ Üniversitesi; 57188793355The central finding of this research is that the Turkish agricultural marketing Co-operative movement has failed in its primary roles - to encourage effective self-help amongst farmers, and to provide an efficient marketing service for its members' producePublication Effect on choline on clonidine withdrawal(Masson Editeur, 1982) Arslan, Yenal; Kavaklı, Burçin; Ulus, İsmail H.; Kıran, Burhan Kemal; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; D-5340-2015; 6602384484; 6603024521; 7004271086; 7004830308Publication Investigations into new outerwear stitches based on the interlock principle(Melliand Textilberichte Kg, 1985) Tasmacı, M.; Uludağ Üniversitesi; 6508331003The suitability of interlock jacquard long-loop stitches for outerwear, as compared with other types of stitches, is discussed. Tests based on DIN standards were carried out to measure the width of the goods, the number of courses and wales, the weight per unit area, the tensile strength and breaking elongation, and the bursting resistance and abrasion resistance. The results showed that the new stitches developed in knitting long loops with jacquard patterns are superior to the conventional cam and jacquard stitches in regard to the density, width, and bursting strength obtained.Publication Close-contact surveys and mass-screening studies for leprosy in Turkey(Lepra, 1988) Saylan, T.; Aytekin, A. H.; Tıp Fakültesi; Toplum Sağlığı Ana Bilim DalıBeginning in 1984, the Department of Dermatology at Istanbul University Medical School and the Department of Public Health of Uludag University Medical School embarked on: a, close contact surveys; and b, mass-screening studies in the Province of Van in Turkey. Methodology and results are described in detail. The total number of cases in the whole country is unlikely to exceed 4300 and leprosy cannot be considered to be a serious public health problem. However there is room for improvement, notably in compliance to prescribed medication, the reduction of disability rates and the better use of general health units.Publication Schizophrenia and schizophrenia-like psychotic epilepsy: An electrophysiological-biochemical correlation(P.J.D. Publications, 1988) Özaşkınlı, Suha; Karakılıç, İlknur Demir; Karaaslan, Ferdi; Pektoylan, T.; Taneli, Bilgen; Taneli, Suna; Tıp Fakültesi; Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı; 6603520984; 6507993732In this study, 15 schizophrenic depressives (SD) with normal EEGs, 17 schizophrenia-like psychotic epilepsy (SLPE) cases with hypersynchronous EEG pathology, but with no epileptic seizures in their medical histories, and 24 healthy control subjects were included. The dexamethasone suppression test (DST) has been used to compare SD and SLPE. Out of 15 patients with SD, 13 (86.67%) had a plasma cortisol concentration higher than 5 μg/dl in the predexamethasone sample taken at 11:00 p.m. Regarding post dexamethasone samples, 8 (53.33%) in their 4:00 p.m. samples and 11 (73.33%) in their 11:00 p.m. samples showed early escape from suppression. Mean values of serum cortisol concentrations were as follows: predexamethasone, 12.63 ± 7.32 μg/dl; postdexamethasone 7.96 ± 7.79 μg/dl at 4:00 p.m. and 9.31 ± 8.97 μg/dl at 11:00 p.m. Out of the 17 SLPE cases, 12 (70.59%) had a plasma cortisol concentration higher than or equal to 5 μg/dl in their 11:00 p.m. predexamethasone blood samples. 2 (11.76%) in their 4:00 p.m. and 3 (17.60%) in their 11:00 p.m. postdexamethasone blood samples showed early escape from suppression. Mean values of serum cortisol concentration were as follows: predexamethasone, 7.15 ± 5.02 μg/dl; postdexamethasone 2.49 ± 2.09 μg/dl at 4:00 p.m. and 3.24 ± 3.44 μg/dl at 11:00 p.m. It was concluded through this research, that two groups of patients with the same clinical symptomatology had actually different aetiologies. SD is an endogenous psychosis, on the other hand SLPE an epileptic phenomenon.Publication Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum(Elsevier, 1988-04-10) Wurtman, Richard J.; Mauron, Charlotte; Blusztajn, Jan Krzysztof; Ulus, İsmail Hakkı; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0001-8438-3122; D-5340-2015This study examined the possibility that membrane phospholipids might be a source of choline used for acetylcholine (ACh) synthesis. Slices of rat striatum or cerebellum were superfused with a choline-free or choline-containing (10, 20 or 40 μM) physiological solution with eserine, for alternating 20 min periods of rest or electrical stimulation. Superfusion media were assayed for choline and ACh, and slice samples taken before and after stimulation were assayed for choline, ACh, various phospholipids, protein and DNA. The striatal slices were able to sustain the stimulation-induced release of ACh, releasing a total of about 3 times their initial ACh contents during the 8 periods of stimulation and rest. During these 8 cycles, 885 pmol/μg DNA free choline was released from the slices into the medium, an amount about 45-fold higher than the initial or final free choline levels in the slices. Although repeated stimulation of the striatal slices failed to affect tissue levels of free choline or ACh, this treatment did cause significant, dose-related (i.e., number of stimulation periods) stoichiometric decreases in tissue levels of phosphatidylcholine (PC) and of the other major phospholipids; tissue protein levels also declined significantly. Addition of exogenous choline to the superfusion medium produced dose-related increases in resting and evoked ACh release. The choline also fully protected the striatal slices from phospholipid depletion for as many as 6 stimulation periods. Cerebellar slices liberated large amounts of free choline into the medium but did not release measurable quantities of ACh; their phospholipid and protein levels did not decline with electrical stimulation. These data show that membrane phospholipids constitute a reservoir of free choline that can be used for ACh synthesis. When free choline is in short supply, ACh synthesis and release are sustained at the expense of this reservoir. The consequent reduction in membrane PC apparently is associated with a depletion of cellular membrane. The use of free choline by cholinergic neurons for two purposes, the syntheses of both ACh and membrane phospholipids, may thus impart vulnerability to them in situations where the supply of free choline is less than that needed for acetylation.Publication Giant lymphoid hamartoma of mediastinum (Castleman's Disease)(Georg Thieme Verlag, 1990) Özkan, Hayati; Tolunay, Şahsene; Gözü, Oktay; Özer, Z. G.; Tıp Fakültesi; Tıp Fakültesi; Tıp Fakültesi; Patoloji Ana Bilim Dalı; Göğüs Kalp Damar Cerrahisi Ana Bilim Dalı; Göğüs Hastalıkları Ana Bilim DalıThe giant lymphoid hamartoma is known as a rare, benign, large, solitary, encapsulated mass of lymphoid tissue. It frequently involves mediastinum or pulmonary hilum. It may also occur in other various locations. Few of the patients may have general Symptoms. The disease has been divided into two variants according to microscopic structure. These are hyaline vasculartype and plasma-cell type. The hyaline vasculartype is benign but the plasma-cell type meets malignancy criteria, so that the plasma-cell type has been subject to discussion whether it is suited to chemothorapy or not. Our case was a 55-year-old male with persistent cough. There was a mass having a size of 6 centimeters on left pulmonary hilum on ehest radiograph. Left thoracotomy was performed and a hilar lymphoid mass removed. The biopsy Unding was “hyaline vascular type giant lymphoid hamartoma”. No other therapy was done. Patient is well six months after the operation.Publication Repair of vesical fistulae using lyophilised human dura(Blackwell Science, 1990) Şimşek, U.; Oktay, M.; Özyurt, Mustafa; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 6602224715; 8081916700; 6602172127Publication Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity(Lippincott-Raven Publications, 1991) Kiran, B. Keerthi; Arslan, Birsen Yiğit; Ulus, İsmail Hakkı; Savcı, Vahide; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; D-5340-2015; 56698581000; 7004271086; 6603687024Intracerebroventricular (i.c.v.) injection of choline (50-150-mu-g) increased blood pressure (SP) and decreased heart rate (HR) in freely moving rats. Intracerebroventricular pretreatment of rats with mecamylamine (50-mu-g) blocked the reduction in HR and reduced the increase in SP induced by i.c.v. choline (150-mu-g). Central muscarinic blockade with atropine (10-mu-g, i.c.v.) reduced the pressor response to i.c.v. choline (150-mu-g) by about 70%, without influencing the decrease in HR. The decrease in HR induced by i.c.v. choline was prevented by intraarterial (i.a.) treatment of atropine methylnitrate (2 mg/kg). Intracerebroventricular choline (150-mu-g) produced a fivefold increase in catecholamine concentrations in adrenal venous plasma. Bilateral adrenalectomy reduced, but did not block, choline's effect on SP. Intracerebroventricular choline (150-mu-g) showed an ability to increase and restore SP in rats subjected to spinal cord transection or pretreatment with hexamethonium (15 mg/kg, i.a.) or with phentolamine (10 mg/kg, i.a.). Intracerebroventricular choline (150-mu-g) increased plasma vasopressin (VP) levels from 2.2 +/- 0.4 to 25.6 +/- 2.5 pg/ml. Pretreatment of rats with a VP antagonist reduced the pressor response to i.c.v. choline. It is concluded that (a) the reduction in HR results from a central nicotinic receptor-mediated increase in vagal tone, (b) the increase in SP appears to be due to activation of both nicotinic and muscarinic central cholinergic receptors, and that (c) the central activation of the adrenal medulla and the increase in plasma levels of VP are involved in the pressor response to i.c.v. choline.Publication Public attitudes toward organ donation- A survey in a Turkish community(Springer Verlag, 1991-07-01) Bilgel, Halil; Bilgel, Nazan; Okan, Necla; Kılıçturgay, Sadık; Özen, Yilmaz; Korun, Nusret; Tıp Fakültesi; Tıp Fakültesi; Halk Sağlığı Ana Bilim Dalı; Genel Cerrahi Ana Bilim Dalı; 0000-0002-4539-5849A survey of public attitudes toward organ donation and transplantation was conducted in a Turkish community. The 1030 subjects were chosen using a random, stratified method. Some 50.5 % of those interviewed were willing to donate their organs while 33.7 % refused and 15.8 % were uncertain. A total of 53.6% said they would consent to donate a deceased relative's organs. Reasons for refusal to donate organs were as follows: fear that their body would be cut into pieces (43.8 %), religious beliefs (26.2%), no reason (23.1%) and the belief that they would need their body and organs for their second life (6.9 % ). Attitudes toward organ donation were clearly related to level of education, age, sex, and socioeconomic status.Publication Comparison of BCG vaccination at birth and at third month of life(British Medical Journal Publication Group, 1992-08-28) Çavuşoğlu, Bülent; Ildırım, İbrahim; Sapan, Nihat; Tıp Fakültesi; Pediatri Ana Bilim DalıTuberculosis is an important health problem in developing countries and the BCG vaccine plays an important part in preventing the disease. There are different reports about the preventive value of BCG. Some of them claim that it is satisfactory while others suggest that it provides little protection. There are also varying ideas about the optimum time to vaccinate babies, some studies suggesting that late vaccination confers a high degree of protection. This prospective controlled study has been undertaken to evaluate the value of BCG vaccine given to babies during their first three days of life versus its value when given in their third month of life. Evaluation was measured by the results of tests with purified protein derivative (PPD), by vaccine scars, and by the complications of the vaccine. It was found that BCG given at the end of the third month provides a higher rate of response and fewer complications than when given during the first three days of life.Publication Fiber alignment and straightening in opening for open-end spinning(Textile Research Inst, 1993) Acar, Memiş; King, Tim G.; Özipek, Bülent; Ülkü, Şükriye; Mühendislik Fakültesi; Tekstil Mühendisliği BölümüSliver separation is an essential operation in open-end spinning. Ideally, the sliver should be separated down to individual fibers, each of which is transported in a fully extended configuration. In reality, however, fiber behavior is far from ideal. Because yarn properties are affected by the effective fiber length, alignment of fibers in the air flow should be achieved and maintained, and the fibers must be delivered onto the spinning surface of the spinner in a parallel, well oriented condition. To obtain straight fibers in the air flow to the twisting process, the fibers must be removed in a straightened form, or straightened during removal, from the pin-clothing of the opening roller.Publication The effects of cimetidine on serum testosterone levels(Elsevier Sci Ireland, 1993) Küçükkömürcü, S.; Kimya, Yalçın; Bilici, Kübra; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 6507291599; 6603919968; 6504783084Publication Scintigraphic detection of splenosis: Superiority of tomographic selective spleen scintigraphy(Blackwell Science Ltd, 1993-07-19) Güneş, İlknur; Yılmazlar, Tuncay; Sarıkaya, Ilhan; Akbunar, T; Irgıl, Ceyhun; Tıp Fakültesi; Tıp Fakültesi; Nükleer Tıp Ana Bilim Dalı; Genel Cerrahi Ana Bilim Dalı; 16207103300; 6701800362; 6506964123; 35721956600We used scintigraphy with sulphur colloid and heat-damaged red cells to detect splenosis after splenectomy in 19 patients 7 to 69 months after injury. We compared planar and tomographic selective spleen scintigraphy using heat-damaged red cells with subtracted planar colloid scintigraphy, and showed that the most sensitive method was tomographic selective splenic scintigraphy. The incidence of splenosis was 58% with this method, the other techniques detecting abnormalities in 21% and 26% of the patients.Publication Microvascular transfers of serratus anterior muscles in rats(Springer Verlag, 1994) Şafak, Erhan; Özcan, Mesut; Tıp Fakültesi; Plastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı; 57196530734; 7102067678The serratus anterior muscle in the rat is supplied by the serratus division of thoracodorsal vessels, in a pattern similar to man. The serratus anterior muscles were transferred to the groin area as a free muscle flap in 17 rats and as a free muscle graft in 13 rats. In the free muscle flap group, the serratus anterior muscles of 8 of 10 rats survived; histological examination showed them to be viable and the vascular anastomoses were patent at the 30th day. In the free muscle graft group, all of the muscle grafts became necrotic. As a result, it is concluded that the microvascular transfer of serratus anterior muscles in rats is a useful small animal model for microsurgical laboratory training of clinical free flap transfers and also for performing pharmacological and biochemical studies in transplanted muscle.Publication Cerebrospinal-fluid interleukin-1-beta interleukin-1 receptor antagonist balance and tumor-necrosis-factor-alpha concentrations in tuberculous, viral and acute bacterial-meningitis(Scandinavian University Press, 1994) Akalın, Halis; Akdış, A.C.; Mıstık, Reşit; Helvacı, Safiye; Kılıçturgay, Kaya; Tıp Fakültesi; 57207553671; 6602564624; 6602103491; 6701350394The levels of interleukin-1 beta, IL-1 receptor antagonist and tumor necrosis factor-alpha (TNF-alpha) were analyzed in 19 cases of tuberculous, 14 cases of viral, and 22 cases of acute bacterial meningitis, and in 18 control: subjects, 20 patients (91%) with acute bacterial and 8(42%) with tuberculous meningitis had detectable amounts of TNF-alpha in the initial cerebrospinal fluid (CSF) sample (mean 1044 +/- 131 pg/ml, range 95-1950, and mean 61 +/- 23 pg/ml, range 25-300, respectively), whereas TNF-alpha was not detectable in any of the patients with viral meningitis or in any of the control subjects. IL-1 beta levels were 767 +/- 110 pg/ml (185-2000) in acute bacterial, 345 +/- 63 pg/ml (50-670) in tuberculous, 257 +/- 70 pg/ml (20-700) in viral meningitis, and 37 +/- 4 pg/ml (10-68) in control subjects. Il-1 receptor antagonist concentrations were significantly elevated in all meningitis groups, without significant differences between the groups. Il-1 receptor antagonist levels were 2487 +/- 62 pg/ml (2250-2950) in acute bacterial, 2216 +/- 82 pg/ml (1350-2550) in tuberculous and 1985 +/- 92 pg/ml (650-2500) in viral meningitis, and 154 +/- 26 pg/ml (20-245) in control CSF samples. A positive correlation was found between TNF and IL-1 beta levels (p < 0.01), and TNF levels and conscious state (p < 0.05). The ratio of concentrations of IL-1 receptor antagonist to IL-1 beta was 3.2 in acute bacterial meningitis, 6.9 in tuberculous meningitis and 8.3 in viral meningitis. This ratio was significantly different between the acute bacterial meningitis group and the other groups (p < 0.01), which indicates that the balance between cytokines and antagonists is of importance for the pathogenicity and diagnosis of central nervous system infections.Publication The adipofascial turn-over flap for the coverage of finger defects(Springer Verlag, 1994) Karacalar, A.; Özcan, M.; Tıp Fakültesi; Plastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı; 7004405636; 7102067678This procedure was used to resurface finger defects in seven cases. The flaps survived completely, except one which had a 20% loss. The clinical results and pertinent literature are described and discussed.Publication Embeddings of nonorientable surfaces with totally reducible focal set(Oxford Univ Press United Kingdom, 1994) Carter, Sheila; Ezentaş, Rıdvan; Fen Edebiyat Fakültesi; Matematik BölümüIn an earlier paper [5] we introduced the idea of an immersion f:M W with totally reducible focal set.Such an immersion has the property that, for all peM, the focal set with base p is a union of hyperplanes in the normal plane to f(M) at .Trivially, this always holds if n=m+1 so we only consider n > m + 1.In [5] we showed that if M2 is a compact surface then for all n>4 there is a substantial immersion:A/2 R with totally reducible focal set. Further, if M2 is orientable or is a Klein bottle or a Klein bottle with handles then/:M2 W can be taken to be an embedding.Here we show that if M2 is a projective plane or a projective plane with handles then for all 5 there exists a substantial embedding f:M2 M with totally reducible focal set although,by arguments of M. Gromov and E. G. Rees,for n=4 such an embedding does not exist.Publication Opinions of Uludag-University Medical-Schools research assistants about the teaching of basic medical sciences(Pergamon-Elsevier Science, 1995) Dirican, Melahat; Güler, Asuman H.; Tıp Fakültesi; Biyokimya Ana Bilim Dalı; AAG-6985-2021; 6601919847; 36763508300Research Assistants were interviewed to obtain their opinions about undergraduate teaching of the basic medical sciences in Turkish medical schools. Most of them said that Physics, Chemistry, Biology, Biostatistic, Biophysics and Genetics should be taught in the first year, while Physiology, Anatomy and Histology should be taught in the second year. In regard to Biochemistry, opinions were almost equally distributed whether it was taught in the first or second or first, second and third years. Two-fifths of the assistants said that Microbiology courses should be given in the second year, and the remaining three-fifths suggested that it would be better if it is given in the second and third years.Publication General practitioners' opinions about the basic sciences in relation to medicine(Pergamon-Elsevier Science, 1995) Ulukaya, Engin; Güler, A. H.; Tıp Fakültesi; Biyokimya Ana Bilim Dalı; K-5792-2018; 6602927353; 36763508300In Turkey in recent years there has been a growth in interest in the basic sciences amongst medical staff.The best indicator of this is the increase in the numbers of general practitioners who are choosing the basic sciences as their specialist areas.There are various reasons for this, including the fact that the number of general practitioners has increased in the last decade, that staff tenure has been increased in the basic sciences and especially because clinical branches have enough doctors and are saturated.In our survey,using a group of general practitioners living in Bursa (a city in Turkey, south of Istanbul) we have tried to understand their opinions about the basic sciences and describe here some of the more interesting results of our findings.